Leptin regulates proinflammatory immune responses
نویسندگان
چکیده
منابع مشابه
Leptin regulates proinflammatory immune responses.
Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality. Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity. It is unclear, however, whether defective leptin-dependent signal transduction directly pr...
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Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...
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Adipose dysfunction resulting from chronic inflammation and impaired adipogenesis has increasingly been recognized as a major contributor to obesity-mediated insulin resistance, but the molecular mechanisms that maintain healthy adipocytes and limit adipose inflammation remain unclear. Here, we used genetic and pharmacological approaches to delineate a novel role for sphingosine kinase 1 (SK1) ...
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Higher serum immunoglobulin (Ig) levels are usually observed in females more than in males of several mammalian species, including man. Females also show a quantitatively and qualitatively enhanced capacity to produce antibodies after immunization (1-7). Moreover, during their fertile period, women have remarkably higher incidences of autoimmune diseases (8, 9). On the other hand, reports exist...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 1998
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fsb2fasebj.12.1.57